| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:DYRKs-IN-1
CAS:1387090-01-8
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:DYRKs-IN-1;DYRKsIN1,DYRKs IN 1
CAS:1387090-01-8
Purity:98% Package:5 mg
|
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| | DYRKs-IN-1 Basic information |
| Product Name: | DYRKs-IN-1 | | Synonyms: | DYRKs-IN-1;DYRKsIN1,DYRKs IN 1;Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo- | | CAS: | 1387090-01-8 | | MF: | C30H30ClN7O4 | | MW: | 588.06 | | EINECS: | | | Product Categories: | | | Mol File: | 1387090-01-8.mol |  |
| | DYRKs-IN-1 Chemical Properties |
| density | 1.53±0.1 g/cm3(Predicted) | | pka | 10.84±0.70(Predicted) |
| | DYRKs-IN-1 Usage And Synthesis |
| Description | DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor and has antitumor activity. | | in vitro | From a data-mining effort, the team has discovered analogues of pyrido[2,3-d]pyrimidines as potent enantio-selective inhibitors of DYRK1B. Cells treated with a tool compound from this series showed the same cellular effects as down regulation of DYRK1B with siRNA._x000D_
_x000D_
Reference: Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. https://pubmed.ncbi.nlm.nih.gov/24239188/ | | target | DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. |
| | DYRKs-IN-1 Preparation Products And Raw materials |
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