| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:ENMD 547
CAS:644961-61-5
Package:200Mg,20Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:ENMD 547;6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone HydrobroMide; 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine MonohydrobroMide
CAS:644961-61-5
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | ENMD 547 Basic information |
| | ENMD 547 Chemical Properties |
| | ENMD 547 Usage And Synthesis |
| Uses | A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model. | | Uses | ENMD 547 can be used as a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. |
| | ENMD 547 Preparation Products And Raw materials |
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