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| Product Name: | FC 131 | | Synonyms: | Cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl];FC131,FC-131;cyclo(2Nal-Gly-D-Tyr-Arg-Arg) | | CAS: | 606968-52-9 | | MF: | C36H47N11O6 | | MW: | 729.83 | | EINECS: | | | Product Categories: | CXCR4 antagonist. | | Mol File: | 606968-52-9.mol |  |
| | FC 131 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml | | pka | 9.89±0.15(Predicted) | | form | Powder | | Water Solubility | Soluble to 2 mg/ml in water |
| | FC 131 Usage And Synthesis |
| Description | C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM). FC 131 derivatives can be used for imaging CXCR4 and elucidating its function. | | Uses | Cyclo[3-?(2-?naphthalenyl)?-?L-?alanylglycyl-?D-?tyrosyl-?L-?arginyl-?L-?arginyl] is a CXCR4 antagonist with anti-HIV properties. | | Definition | ChEBI: Cyclo[3-(2-naphthalenyl)-l-alanylglycyl-d-tyrosyl-l-arginyl-l-arginyl] is an oligopeptide. |
| | FC 131 Preparation Products And Raw materials |
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