Company Name: |
Haoyuan Chemexpress Co., Ltd.
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Tel: |
021-58950125 |
Email: |
info@chemexpress.com |
Products Intro: |
Product Name:Kif15-IN-2 CAS:672926-33-9 Purity:>98% Package:2170RMB/2mg
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Company Name: |
MedChemexpress LLC
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Tel: |
021-58955995 |
Email: |
sales@medchemexpress.cn |
Products Intro: |
Product Name:Kif15-IN-2 CAS:672926-33-9 Purity:>98% Package:2170RMB/2mg
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| Kif15-IN-2 Basic information |
Product Name: | Kif15-IN-2 | Synonyms: | Kif15-IN-2;(alphaS)-1,4-Dihydro-alpha-(1-methylethyl)-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiazolyl]-2,4-dioxo-3(2H)-quinazolineacetamide;Kif15 inhibitor 2;3(2H)-Quinazolineacetamide, 1,4-dihydro-α-(1-methylethyl)-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiazolyl]-2,4-dioxo-, (αS)-;Kif15IN2,Kif-15-IN-2,Kif15 IN 2 | CAS: | 672926-33-9 | MF: | C20H20N6O4S | MW: | 440.48 | EINECS: | | Product Categories: | | Mol File: | 672926-33-9.mol | |
| Kif15-IN-2 Chemical Properties |
density | 1.409±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | solid | pka | 7.58±0.50(Predicted) |
| Kif15-IN-2 Usage And Synthesis |
Biological Activity | kif15-in-2, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withkif11 [3]. | references | [1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318. [2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96. [3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717. |
| Kif15-IN-2 Preparation Products And Raw materials |
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