- Oxolamine
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- $0.00 / 25KG
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2023-09-01
- CAS:959-14-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- Oxolamine
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- $1.00 / 1PCS
-
2021-06-01
- CAS:959-14-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Oxolamine Basic information |
| Product Name: | Oxolamine | | Synonyms: | 1,2,4-OXADIAZOLE,5-(2-DIETHYLAMINO)ETHYL)-3-PHENYL-;Oxolamine (base and/or unspecified salts);683 M;683M;AF-438;OXOLAMINE;5-[2-(diethylamino)ethyl]-3-phenyl-1,2,4-oxadiazole;1,2,4-Oxadiazole-5-ethanamine, N,N-diethyl-3-phenyl- | | CAS: | 959-14-8 | | MF: | C14H19N3O | | MW: | 245.32 | | EINECS: | 213-493-4 | | Product Categories: | | | Mol File: | 959-14-8.mol |  |
| | Oxolamine Chemical Properties |
| Melting point | 25°C | | Boiling point | bp0.4 127° | | density | 1.0516 (rough estimate) | | refractive index | 1.5310 (estimate) | | pka | 9.40±0.25(Predicted) | | form | Liquid | | LogP | 2.393 | | CAS DataBase Reference | 959-14-8(CAS DataBase Reference) |
| Toxicity | LD50 oral in rat: > 2gm/kg |
| | Oxolamine Usage And Synthesis |
| Originator | Bredon,Organon | | Uses | Oxolamine is a antiinflammatory drug used as a cough suppressant. | | Definition | ChEBI: N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine is an oxadiazole and a ring assembly. | | Manufacturing Process | 18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g. | | Therapeutic Function | Antitussive, Antiinflammatory | | Safety Profile | Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx. |
| | Oxolamine Preparation Products And Raw materials |
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