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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Suppliers list
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Products Intro: Product Name:2-Amino-3-phosphonopropanoic acid
CAS:5652-28-8
Purity:98% Min. Package:5KG;1KG
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:DL-AP3
CAS:5652-28-8
Purity:98% Package:$38.9/10mg;$88.9/25mg;$137.9/50mg;$248.9/100mg;Bulk package Remarks:98%
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:DL-AP3
CAS:5652-28-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Email: marketing@energy-chemical.com
Products Intro: Product Name:D,L-2-Amino-3-phosphonopropionic Acid
CAS:5652-28-8
Purity:NULL Package:100mg;2.5g;250mg;50mg Remarks:NULL
Company Name: Shanghai Haohong Pharmaceutical Co., Ltd.  
Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Products Intro: Product Name:DL-AP3
CAS:5652-28-8
Purity:98%
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Basic information
Product Name:(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
Synonyms:(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST;2-Amino-3-phosphonopropionic acid;2-AP3;Alanine, 3-phosphono-
CAS:5652-28-8
MF:C3H8NO5P
MW:169.07
EINECS:
Product Categories:
Mol File:5652-28-8.mol
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Structure
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Chemical Properties
Boiling point 481.6±55.0 °C(Predicted)
density 1.763±0.06 g/cm3(Predicted)
solubility PBS (pH 7.2): 2 mg/ml
form White powder.
pka1.22±0.10(Predicted)
Safety Information
HS Code 2931499090
MSDS Information
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Usage And Synthesis
DescriptionMetabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.
UsesDL-2-Amino-3-phosphonopropionic acid (AP3) is an inhibitor of phosphoserine phosphatase and mGluR. Also known as the antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.
DefinitionChEBI: 2-amino-3-phosphonopropanoic acid is a non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It has a role as a metabotropic glutamate receptor antagonist and a human metabolite. It is a non-proteinogenic alpha-amino acid, a member of phosphonic acids and an alanine derivative.
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Preparation Products And Raw materials
Tag:(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST(5652-28-8) Related Product Information
QUISQUALIC ACID (+/-)-ALPHA-METHYL-(4-SULFONOPHENYL)GLYCINE (2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE (S)-MPPG CPPG JNJ 16259685 (2R,4R)-APDC L-AP3 MPPG 4-Phosphonophenylglycine AIDA L-AP4 IBOTENIC ACID 3-PHOSPHONOPROPIONIC ACID