4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BW 755C
CAS:66000-40-6
Package:1 mL * 10mM (in DMSO);10 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501
Email: product@acmec-e.com
Products Intro: Product Name:4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
CAS:66000-40-6
Purity:96% Package:50mg
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:BW 755C
CAS:66000-40-6
Purity:>=95.0% Package:$160.9/5mg;$260.9/10mg;Bulk package Remarks:95.0%
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:BW 755C
CAS:66000-40-6
Purity:95% Package:1G;10G;100G Remarks:Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflamma
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:BW 755C
CAS:66000-40-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Basic information
Product Name:4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
Synonyms:4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine;BW-755C;CGS-13592;2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine;3-amino-1-<3-(trifluoromethyl)phenyl>-2-pyrazoline;1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-;1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine
CAS:66000-40-6
MF:C10H10F3N3
MW:229.2017096
EINECS:2660518
Product Categories:
Mol File:66000-40-6.mol
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Structure
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Chemical Properties
Boiling point 308.5±52.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;25mg/ml in dimethyl formamide
form crystalline solid
pka2.57±0.70(Predicted)
Safety Information
MSDS Information
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Usage And Synthesis
Biological Activitybw 755c is a dual inhibitor of 5-lipoxygenase (5-lo) and cyclooxygenase (cox) pathways.constitutive cyclooxygenase (cox-1) is present in cells under physiological conditions, whereas cox-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. since 5-lipoxygenase (5-lo) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid in the first step of the leukotriene pathway, 5-lo inhibitors should prevent leukotriene biosynthesis and thus prove useful in the treatment of allergic asthma.
in vitroprevious study found that bw 755c and other nonsteroidal antiinflammatory drugs including diclofenac, acetaminophen, and naproxen showed approximately equipotent inhibitory effects on cox-1 and cox-2 in intact cells. whereas, bf 389 was the most potent and most selective inhibitor of cox-2 in intact cells [1].
in vivoan animal study was conducted to examine whether bw-755c delayed neuronal death in the hippocampal ca1 sector in mongolian gerbils after 5 minutes of forebrain ischemia. gerbils were injected with bw-755c. seven days after ischemic insult, the animals were perfusion-fixed, and the neuronal density in the hippocampal ca, sector was estimated. results showed that in ischemic gerbils with vehicle administration, the average neuronal density was 13 for bw-755c. in ischemic gerbils treated with 30 mg/kg bw-755c, the average neuronal densities was 14 [2].
IC 500.75 μm, 0.65 μg/ml, and 1.2 μg/ml for 5-lo, cox-1, and cox-2, respectively
references[1] mitchell, j. a.,akarasereenont, p.,thiemermann, c., et al. selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. proceedings of the national academy of sciences of the united states of america 90, 11693-11697 (1993).
[2] nakagomi t, sasaki t, kirino t, tamura a, noguchi m, saito i, takakura k. effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. stroke. 1989 jul;20(7):925-9.
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Preparation Products And Raw materials
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