(±)-TRANS-ACPD
中文名称 | (±)-TRANS-ACPD |
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中文同义词 | 化合物(±)-TRANS-ACPD;TRANS-1-氨基环戊烷-1,3-二羧酸 |
英文名称 | (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID |
英文同义词 | (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID;TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID;(+/-)-TRANS-ACPD;TRANS-(+/-)-ACPD;TRANS-ACPD;TRANS(+-)-ACPD EXCITATORY AMINO ACID;trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate;trans-(±)-ACPD monohydrate |
CAS号 | 67684-64-4 |
分子式 | C7H11NO4 |
分子量 | 173.17 |
EINECS号 | |
相关类别 | |
Mol文件 | 67684-64-4.mol |
结构式 |
(±)-TRANS-ACPD 性质
沸点 | 352.7±42.0 °C(Predicted) |
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密度 | 1.452±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | 水中的溶解度为1mg/mL |
酸度系数(pKa) | 2.11±0.40(Predicted) |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH |
mGluR
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Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC 50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC 50 values are 480-850 μM).
Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-19434 | (±)-TRANS-ACPD trans-ACPD | 67684-64-4 | 2mg | 660元 |
2024/04/30 | HY-19434 | (±)-TRANS-ACPD trans-ACPD | 67684-64-4 | 10mM * 1mLin DMSO | 726元 |