3-methyl toxoflavin
| 中文名称 | 3-methyl toxoflavin |
|---|---|
| 中文同义词 | 化合物3-METHYL TOXOFLAVIN;1,3,6-三甲基嘧啶并[5,4-E][1,2,4]三嗪-5,7(1H,6H)-二酮 |
| 英文名称 | 3-methyl toxoflavin |
| 英文同义词 | 3-methyl toxoflavin;Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl-;Inhibitor,3 Methyltoxoflavin,3-Methyltoxoflavin,3Methyltoxoflavin,inhibit;1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione |
| CAS号 | 32502-62-8 |
| 分子式 | C8H9N5O2 |
| 分子量 | 207.19 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 32502-62-8.mol |
| 结构式 |  |
3-methyl toxoflavin 性质
| 沸点 | 285.0±23.0 °C(Predicted) |
|---|---|
| 密度 | 1.56±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：150 mg/mL（723.97 mM） |
| 酸度系数(pKa) | -1.80±0.20(Predicted) |
IC50: 170 nM (PDI).
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-111117 | 3-Methyltoxoflavin | 1 mg | 681元 | |
| 2024/04/30 | HY-111117 | 3-methyl toxoflavin 3-Methyltoxoflavin | 32502-62-8 | 10mM * 1mLin DMSO | 1650元 |