- Bis-PEG6-NHS ester
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- $0.00 / 5g
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2024-03-25
- CAS:1526718-98-8
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | Bis-PEG6-NHS ester Basic information |
| Product Name: | Bis-PEG6-NHS ester | | Synonyms: | BIS-PEG6-NHS;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;Di-NHS Ester-PEG6 | | CAS: | 1526718-98-8 | | MF: | C24H36N2O14 | | MW: | 576.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1526718-98-8.mol |  |
| | Bis-PEG6-NHS ester Chemical Properties |
| solubility | Soluble in DMSO, DCM |
| | Bis-PEG6-NHS ester Usage And Synthesis |
| Description | Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Biological Activity | Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | PEGs | Alkyl/ether | |
| | Bis-PEG6-NHS ester Preparation Products And Raw materials |
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