Oxotremorine M
中文名称 | Oxotremorine M |
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中文同义词 | 碘化氧化震颤素M;化合物 T12339 |
英文名称 | trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide |
英文同义词 | trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide;Oxotremorine M (iodide);CPD3509 |
CAS号 | 3854-04-4 |
分子式 | C11H19IN2O |
分子量 | 322.19 |
EINECS号 | |
相关类别 | |
Mol文件 | 3854-04-4.mol |
结构式 |
Oxotremorine M 性质
储存条件 | Desiccate at -20°C |
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溶解度 | DMSO:125 mg/mL(387.97 mM;需要超声波) |
形态 | 粉末 |
水溶解性 | Soluble to 100 mM in water |
Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence.
Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC
50
of 0.22 μM. Oxotremorine M iodide has EC
50
s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-101372A | Oxotremorine M iodide | 5 mg | 312元 | |
2024/04/30 | HY-101372A | Oxotremorine M Oxotremorine M iodide | 3854-04-4 | 10mM * 1mLin DMSO | 550元 |