氢化可的松环戊丙酸酯
| 中文名称 | 氢化可的松环戊丙酸酯 |
|---|---|
| 中文同义词 | 氢化可的松环戊丙酸酯;氢化可的松环磷酸酯;化合物 T19358;氢化可的松杂质23 |
| 英文名称 | HYDROCORTISONE CYPIONATE (200 MG) |
| 英文同义词 | 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-cyclopentanepropionate;HYDROCORTISONE CYPIONATE;Hydrocortisone 21-cypionate;21-(3-Cyclopentyl-1-oxopropoxy)-11β,17α-dihydroxypregn-4-ene-3,20-dione;(11β)-21-(3-Cyclopentyl-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione;Hydrocortisone cipionate;HYDROCORTISONE CYPIONATE (200 MG);Hydrocortisone cypiote |
| CAS号 | 508-99-6 |
| 分子式 | C29H42O6 |
| 分子量 | 486.64 |
| EINECS号 | 208-091-0 |
| 相关类别 | |
| Mol文件 | 508-99-6.mol |
| 结构式 |  |
氢化可的松环戊丙酸酯 性质
| 沸点 | 645.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（256.86 mM） |
| 酸度系数(pKa) | 12.33±0.70(Predicted) |
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells.