| Company Name: |
Shaanxi Dideu Newmaterial Co., Ltd.
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029-63373950 15353716720 |
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1052@dideu.com |
| Products Intro: |
Product Name:mitoguazone hydrochloride
CAS:7059-23-6
Purity:98% Package:25kg
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| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
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sales@focusbiomolecules.com |
| Products Intro: |
Product Name:Mitoguazone 2HCl
CAS:7059-23-6
Purity:98% by HPLCNMR (Confirms) Package:$70.00/10mg;$260.00/50mg;
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| Company Name: |
Pharma Affiliates
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172-5066494 |
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@pharmaffiliates.com |
| Products Intro: |
Product Name:3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride
CAS:7059-23-6
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| | 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Basic information |
| | 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Chemical Properties |
| Melting point | 256 °C (decomp) | | storage temp. | -20° | | solubility | Soluble in Water (greater than 25 mg/ml). | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. |
| | 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Usage And Synthesis |
| Description | Mitoguazone (7059-23-6) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2?SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3?Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of its ability to inhibit polyamine synthesis.6 | | Definition | ChEBI: A hydrochloride obtained by combining mitoguazone with two molar equivalents of hydrochloric acid. | | References | 1) Wiliams?et al., (1971),?Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun.,?46?288
2) Corti?et al., (1974),?Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J.,?139?351
3) Williams-Ashman and Seidenfeld, (1986),?Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol.,?35?1217
4) Janne and Morris, (1984),?Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J.,?218?947
5) Pegg?et al., (1985)?Induction of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta,?842?111
6) Porter and Janne (2012)?Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248 |
| | 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Preparation Products And Raw materials |
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