4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
中文名称 | 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇 |
---|---|
中文同义词 | 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇;4-甲氧基-3,5-二丙烯基-(1,1'-联苯)-2-醇;4-O-和厚朴酚;4--O-甲基和厚朴酚;化合物 T10153;4-甲基和厚朴酚 |
英文名称 | 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol |
英文同义词 | 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol;2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol;4-O-Methyl honokiol;[1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-;4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol |
CAS号 | 68592-15-4 |
分子式 | C19H20O2 |
分子量 | 280.36 |
EINECS号 | |
相关类别 | 标准品;小分子药物 |
Mol文件 | 68592-15-4.mol |
结构式 |
4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | DMF:33 mg/ml; DMSO:33 mg/ml;乙醇:33 mg/ml;乙醇:PBS (pH 7.2) (1:2): 0.3 mg/ml |
PPARγ
|
NF-κB
|
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells.
4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-U00450 | 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇 4-O-Methyl honokiol | 68592-15-4 | 5mg | 1500元 |
2024/04/30 | HY-U00450 | 4-O-Methyl honokiol | 10 mM * 1 mLin DMSO | 1650元 |