| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:FGTI-2734
CAS:1247018-19-4
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | FGTI-2734 Basic information |
| Product Name: | FGTI-2734 | | Synonyms: | FGTI-2734;2-Pyridinesulfonamide, N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-;pancreatic,patient-derived,geranylgeranyl,farnesyl,inhibit,Farnesyl Transferase,mimetic,FGTI2734,Inhibitor,membrane,Ftase,FGTI-2734,KRAS,FGTI 2734,C-terminal,transferase,tumors,localization | | CAS: | 1247018-19-4 | | MF: | C26H31FN6O2S | | MW: | 510.63 | | EINECS: | | | Product Categories: | | | Mol File: | 1247018-19-4.mol |  |
| | FGTI-2734 Chemical Properties |
| Boiling point | 770.1±70.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:50.0(Max Conc. mg/mL);97.92(Max Conc. mM) | | pka | 6.60±0.10(Predicted) |
| | FGTI-2734 Usage And Synthesis |
| Description | FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor. It can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. | | target | FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. |
| | FGTI-2734 Preparation Products And Raw materials |
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