呋塞米钠
中文名称 | 呋塞米钠 |
---|---|
中文同义词 | 呋塞米钠;速尿钠 |
英文名称 | sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate |
英文同义词 | sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;Fursemide sodium;5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt;FuroseMide (sodiuM);Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;Frusemide Sodium;Sodium furosemide |
CAS号 | 41733-55-5 |
分子式 | C12H12ClN2NaO5S |
分子量 | 354.74 |
EINECS号 | 255-526-5 |
相关类别 | |
Mol文件 | 41733-55-5.mol |
结构式 |
呋塞米钠 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | 二甲基亚砜:≥ 150 mg/mL(425.25 mM) |
IC50: NKCC1 and NKCC2IC50: GABA A receptors
Furosemide sodium (500 µM; 72-96 hours) significantly changes the proliferation rates in MKN45 cells (the poorly differentiated human gastric adenocarcinoma cell line). however, it has no effects on MKN28 cells (the moderately differentiated human gastric adenocarcinoma cell line). The growth rate of MKN45 cells is larger than that of MKN28 cells.Furosemide sodium (10 µM, 30 µM, 100 µM; 45 min exposure)significantly decreases cation channel activity and [Ca(2+)](i) in human erythrocytes drawn from healthy individuals. Tert-butylhydroperoxide similarly enhances the non-selective cation channels activity, increases [Ca(2+)](i) and triggered cell membrane scrambling, however, the effects is significantly blunted by Furosemide sodium again.
Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-B0135A | 呋塞米钠 Furosemide sodium | 41733-55-5 | 500mg | 900元 |
2024/04/30 | HY-B0135A | 呋塞米钠 Furosemide sodium | 41733-55-5 | 10mM * 1mLin DMSO | 990元 |