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Nantong QuanYi Biotechnology Co., Ltd
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| Products Intro: |
Product Name:CGP 12177 hydrochloride
CAS:64208-32-8
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| Company Name: |
ApexBio Technology
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| Tel: |
+ 1-832-696-8203 |
| Email: |
sales@apexbt.com |
| Products Intro: |
Product Name:CGP 12177 hydrochloride
CAS:64208-32-8
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| | (+/-) CGP 12177A Basic information |
| Product Name: | (+/-) CGP 12177A | | Synonyms: | (±)-CGP-12177 hydrochloride, 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1, 3-dihydro-2H-benzimidazol-2-one hydrochloride;4-(3-(tert-Butylamino)-2-hydroxypropoxy)-1H-benzo[d]imidazol-2(3H)-one hydrochloride;(+/-) CGP 12177A;CGP12177A HCl | | CAS: | 64208-32-8 | | MF: | C14H21N3O3.ClH | | MW: | 315.799 | | EINECS: | | | Product Categories: | | | Mol File: | 64208-32-8.mol |  |
| | (+/-) CGP 12177A Chemical Properties |
| storage temp. | Store at RT | | solubility | DMSO: >10mg/mL | | form | solid | | color | white | | Water Solubility | Soluble to 50 mM in water |
| | (+/-) CGP 12177A Usage And Synthesis |
| Uses | CGP 12177 Hydrochloride is a selective β3-adrenoceptor agonist. | | Biological Activity | cgp 12177 hydrochloride is a partial agonist of β3-adrenoceptor and an antagonist of β1- and β2-adrenoceptors with ki values of 0.9, 4 and 88 nm for β1-, β2- and β3-adrenoceptors, respectively.β3-adrenoceptor is exists mainly in adipose tissue and plays an important role in the regulation of thermogenesis and lipolysis.cgp 12177 hydrochloride is a partial agonist of β3-adrenoceptor and an antagonist of β1- and β2-adrenoceptors. in human ventricular myocytes (hvms), cgp12177 slightly activated l-type ca2+ current (ica,l) [1].in sympathectomized (sx) interscapular brown adipose tissue (bat) isolated from rats, cgp-12177 restored normal thyroxine (t4) deiodination, which suggested that cgp-12177 activated 5’-deiodinase type ii through β3-adrenoceptor [2]. in spontaneously hypertensive rats (shr) and normotensive rats, cgp12177 induced vasorelaxant effects and decreased hindquartersperfusion pressure in a dose-dependent way induced by 5-hydroxytryptamine (5-ht), which was inhibited by bupranolol, a β1la-adrenoceptor antagonist. these results suggested that cgp12177 induced vasorelaxant effects through activation of β1la-adrenoceptor [3]. | | storage | Store at RT | | references | [1]. treinys r, zablockaitė d, gendvilienė v, et al. β₃-adrenergic regulation of l-type ca²⁺ current and force of contraction in human ventricle. j membr biol, 2014, 247(4): 309-318.
[2]. hofer d, raíces m, schauenstein k, et al. the in vivo effects of beta-3-receptor agonist cgp-12177 on thyroxine deiodination in cold-exposed, sympathectomized rat brown fat. eur j endocrinol, 2000, 143(2): 273-277.
[3]. holopherne d, mallem my, le strat e, et al. cgp12177-induced haemodynamic and vascular effects in normotensive and hypertensive rats. eur j pharmacol, 2008, 591(1-3): 196-202. |
| | (+/-) CGP 12177A Preparation Products And Raw materials |
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