MICROCOCCIN P1
| 中文名称 | MICROCOCCIN P1 |
|---|---|
| 中文同义词 | 微球菌素P1;化合物 T12033 |
| 英文名称 | 13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P |
| 英文同义词 | 13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P;Micrococcin P1;Brn 1070340;Micrococcin p, 13',19'-didehydro-19'-deoxy-28,44-dihydro-44-hydroxy-;[2,4'-Bithiazole]-4-carboxamide, 2'-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazac...;MQGFYNRGFWXAKA-QMXXNAFJSA-N |
| CAS号 | 67401-56-3 |
| 分子式 | C48H49N13O9S6 |
| 分子量 | 1144.37 |
| EINECS号 | |
| 相关类别 | 微生物代谢物 |
| Mol文件 | 67401-56-3.mol |
| 结构式 |  |
MICROCOCCIN P1 性质
| 密度 | 1.1650 (rough estimate) |
|---|---|
| 折射率 | 1.6700 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：可溶； DMSO：可溶；乙醇：可溶；甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.68±0.46(Predicted) |
Micrococcin P1 是一种大环肽抗生素，是一种有效的丙型肝炎病毒 (HCV) 抑制剂，EC50 范围为 0.1-0.5 μM。Micrococcin P1 对革兰氏阳性细菌菌株具有体外抗菌活性，对金黄色葡萄球菌 1974149 菌株，粪肠球菌 1674621 菌株和化脓性链球菌 1744264 菌株的 MIC 值分别为 2 μg/ mL，1 μg/ mL 和 1 μg/ mL。Micrococcin P1 还是疟疾寄生虫恶性疟原虫的有效抑制剂。
HCV; Bacterial; Parasite
Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC 80 of about 1 mM with potency comparable with that of isoniazid.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-125728 | MICROCOCCIN P1 Micrococcin P1 | 67401-56-3 | 500μg | 6400元 |
| 2023/03/20 | HY-125728 | MICROCOCCIN P1 Micrococcin P1 | 67401-56-3 | 1mg | 15500元 |