BX 430
中文名称 | BX 430 |
---|---|
中文同义词 | 化合物BX430;1-(2,6-二溴-4-异丙基苯基)-3-(吡啶-3-基)脲;BX 430,P2X4变构拮抗剂 |
英文名称 | BX 430 |
英文同义词 | BX 430;N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea;Urea, N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-;1-(2,6-Dibromo-4-isopropylphenyl)-3-(pyridin-3-yl)urea;P2X Receptor,Ca channels,BX430,chronic,channels,species,P2XRs,Inhibitor,disease,Ca2+ channels,BX 430,cardiovascular,P2X4,receptor,specificity,inhibit,Calcium Channel,human,pain,BX-430 |
CAS号 | 688309-70-8 |
分子式 | C15H15Br2N3O |
分子量 | 413.11 |
EINECS号 | |
相关类别 | |
Mol文件 | 688309-70-8.mol |
结构式 |
BX 430 性质
熔点 | 164-168°C |
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储存条件 | 2-8°C |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 白色 |
Target | Value |
hP2X4
(Cell-free assay) | 0.54 μM |
BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC
50
.
BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs.
Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP.
BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-110237 | BX 430 BX430 | 688309-70-8 | 5mg | 850元 |
2024/04/30 | HY-110237 | BX 430 BX430 | 688309-70-8 | 10 mM * 1 mLin DMSO | 940元 |