MYCMI-6
| 中文名称 | MYCMI-6 |
|---|---|
| 中文同义词 | 3-((9-氨基-7-乙氧基吖啶-3-基)偶氮基)吡啶-2,6-二胺;化合物MYCMI-6 |
| 英文名称 | MYCMI-6 |
| 英文同义词 | MYCMI-6;NSC354961;2,6-Pyridinediamine, 3-[2-(9-amino-7-ethoxy-3-acridinyl)diazenyl]-;MYCMI-6(NSC 354961);3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine;NSC 354961,cells,neuroblastoma,cytotoxic,mice,tumor,inhibit,nude,lymphoma,MYCMI-6,athymic,Inhibitor,NSC-354961,MYC-driven,Apoptosis,Myc,c-Myc,MYCMI6,MCF7,MYCMI 6 |
| CAS号 | 681282-09-7 |
| 分子式 | C20H19N7O |
| 分子量 | 373.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 681282-09-7.mol |
| 结构式 |  |
MYCMI-6 性质
| 沸点 | 699.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.46±0.1 g/cm3(Predicted) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 酸度系数(pKa) | 7.53±0.10(Predicted) |
MYCMI-6 (NSC354961) (6.25 μM; 48 hours) selectively suppresses MYC-driven tumor cell growth with high efficacy.
MYCMI-6 significantly inhibits growth of Burkitt’s lymphoma cells (Mutu, Daudi and ST486) - another classical example of a MYC-driven tumor, having translocations of
MYC
to one of the immunoglobulin loci - in a dose-dependent manner with an average GI
50
of 0.5 μM. Treatment of MCF7 cells with the MYCMI-6 for 24 hours significantly decreased MYC:MAX isPLA signals to 7%. Titration showed an IC
50
for inhibition of MYC:MAX of less than 1.5 μM for MYCMI-6 by isPLA. MYCMI-6 inhibits the MYC:MAX heterodimer formation with an IC
50
of 3.8 μM. MYCMI-6 efficiently inhibits anchorage-independent growth of
MYCN
-amplified neuroblastoma cells with GI
50
values of <0.4 μM.
Cell Viability Assay
| Cell Line: | MYCN -amplified neuroblastoma cells (IMR-32, Kelly and SK-N-DZ), MYCN -non-amplified neuroblastoma cells (SK-N-F1, SK-N-AS and SK-N-RA) |
| Concentration: | 6.25 μM |
| Incubation Time: | 48 hours |
| Result: | Reduced growth of the MYCN -amplified cell lines significantly stronger than the MYCN -non-amplified cell lines. |
MYCMI-6 (20 mg/kg; i.p.; daily for 1-2 weeks) induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model.
| Animal Model: | 6-8 weeks old athymic nude mice (bearing MYCN-amplified SK-N-DZ neuroblastoma cells) |
| Dosage: | 20 mg/kg body weight |
| Administration: | I.p.; daily for 1-2 weeks |
| Result: | A dramatic increase in the extension of apoptotic areas in the tumors and a significant increase in non-proliferative areas as determined by Ki67 staining in tumors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-124675 | MYCMI-6 MYCMI-6 | 681282-09-7 | 5mg | 800元 |
| 2024/04/30 | HY-124675 | MYCMI-6 MYCMI-6 | 681282-09-7 | 10 mg | 1120元 |