Log in | Join Free | china | japan | germany

INDEX NAME NOT YET ASSIGNED

Request For Quotation
INDEX NAME NOT YET ASSIGNED Suppliers list
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology  
Tel: 18143011203
Email: ET-market@chemextension.com
Products Intro: Product Name:SIM1
CAS:2719051-84-8
Purity:95%+ Package:1g;5g;10g;25g;50g;100g;
INDEX NAME NOT YET ASSIGNED Basic information
Product Name:INDEX NAME NOT YET ASSIGNED
Synonyms:
CAS:2719051-84-8
MF:C79H98Cl2N14O13S3
MW:1618.81
EINECS:
Product Categories:
Mol File:Mol File
INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
solubility Soluble to 50 mM in DMSO
pka13.52±0.46(Predicted)
Safety Information
MSDS Information
INDEX NAME NOT YET ASSIGNED Usage And Synthesis
Biological ActivitySIM1 is a potent and selective trivalent PROTAC? Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50 values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells.
storageStore at -20°C
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Tag:INDEX NAME NOT YET ASSIGNED(2719051-84-8) Related Product Information