1,2,3,6-四氢-4-吡啶甲酸盐酸盐
| 中文名称 | 1,2,3,6-四氢-4-吡啶甲酸盐酸盐 |
|---|---|
| 中文同义词 | 1,2,3,6-四氢-4-吡啶甲酸盐酸盐;异去甲槟榔次碱盐酸盐;1,2,3,6-四氢-4-吡啶羧酸盐酸盐;异番石榴碱盐酸盐;异四氢烟酸 |
| 英文名称 | 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride |
| 英文同义词 | IsoguvacineHydrochloride>6-tetrahydro-4-pyridinecarboxylic acid hydrochloride;γ-Aminobutyric acid Receptor,Isoguvacine,GABA Receptor,Gamma-aminobutyric acid Receptor,Isoguvacine hydrochloride,inhibit,Inhibitor |
| CAS号 | 68547-97-7 |
| 分子式 | C6H9NO2HCl |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 合成;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 68547-97-7.mol |
| 结构式 |  |
1,2,3,6-四氢-4-吡啶甲酸盐酸盐 性质
| 熔点 | 280 °C(dec.) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | H2O：可溶（如果不立即使用，请冷藏。） |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | Soluble in water (100mM) |
GABA
Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca 2+ -dependent manner and by heteroexchange with external GABA. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | I0871 | 异去甲槟榔次碱盐酸盐 Isoguvacine Hydrochloride | 68547-97-7 | 25mg | 250元 |