| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:NSC-33994
CAS:82058-16-0
Package:500Mg,50Mg
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| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:NSC 33994
CAS:82058-16-0
Purity:>=98%
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:NSC-33994;4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol; (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol
CAS:82058-16-0
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | NSC 33994 Basic information |
| Product Name: | NSC 33994 | | Synonyms: | (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol;4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol;(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI);4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol};G6;NSC 33994;Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]- | | CAS: | 82058-16-0 | | MF: | C28H42N2O2 | | MW: | 438.65 | | EINECS: | | | Product Categories: | Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular signaling. | | Mol File: | 82058-16-0.mol |  |
| | NSC 33994 Chemical Properties |
| Boiling point | 524.7±45.0 °C(Predicted) | | density | 1.040±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥25mg/mL | | form | powder | | pka | 9.20±0.50(Predicted) | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | NSC 33994 Usage And Synthesis |
| Description | NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.1?Suppresses JAK2-V617F-mediated human pathological cell growth?in vitro?and?in vivo2?and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells?in vitro?and?in vivo.4 | | Uses | NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies. | | storage | -20°C | | References | 1) Kiss?et al. (2009),?Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett.,?19?3598
2) Kirabo?et al. (2011),?The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem.,?286?4280
3) Majumder?et al. (2011),?Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry,?50?7774
4) Baskin?et al. (2014),?The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo; PLoS One,?9(8)?e105568 |
| | NSC 33994 Preparation Products And Raw materials |
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