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TCO-PEG4-NHS ester

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TCO-PEG4-NHS ester Suppliers list
Company Name: Xian confluore Biological Technology Co., Ltd.
Tel: +86-15680926068 +86-15680926068
Email: 1924344760@confluore.cn
Products Intro: Product Name:(4E)-TCO-PEG4-NHS ester
CAS:1613439-69-2
Purity:>95.00% Package:50mg
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Products Intro: Product Name:TCO-PEG4-NHS ester
CAS:1613439-69-2
Package:1kg，2kg，5kg，10kg，25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:TCO-PEG4-NHS ester
CAS:1613439-69-2
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou Huarong Pharm Co., Ltd.
Tel: 571-86758373 +8613588754946
Email: sales@huarongpharm.com
Products Intro: Product Name:TCO-PEG4-NHS ester
CAS:1613439-69-2
Purity:0.99 Package:10MG,50MG,100MG,1G
Company Name: Shanghai Huici Pharmaceutical Technology Co., LTD
Tel: +8618917134367
Email: lixing@pharmahuici.com
Products Intro: Product Name:TCO-PEG4-NHS ester
CAS:1613439-69-2
Purity:0.98 Package:1g 5g 25g 50g 100g

TCO-PEG4-NHS ester manufacturers

  • (4E)-TCO-PEG4-NHS ester
  • (4E)-TCO-PEG4-NHS ester pictures
  • $0.00 / 50mg
  • 2024-03-21
  • CAS:1613439-69-2
  • Min. Order: 50mg
  • Purity: >95.00%
  • Supply Ability: 50mg
TCO-PEG4-NHS ester Basic information
Product Name:TCO-PEG4-NHS ester
Synonyms:TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
CAS:1613439-69-2
MF:C24H38N2O10
MW:514.57
EINECS:
Product Categories:
Mol File:1613439-69-2.mol
TCO-PEG4-NHS ester Structure
TCO-PEG4-NHS ester Chemical Properties
density 1.23±0.1 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka11.95±0.46(Predicted)
InChIInChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
InChIKeyZKPMRASGLDBKPF-UPHRSURJSA-N
SMILESC(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6|
Safety Information
MSDS Information
TCO-PEG4-NHS ester Usage And Synthesis
DescriptionTCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition
Biological ActivityTCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

TCO-PEG4-NHS ester Preparation Products And Raw materials
Tag:TCO-PEG4-NHS ester(1613439-69-2) Related Product Information
Gly-PEG3-(4E)-TCO (4E)-TCO-PEG3-amine (2E)-TCO-PNB ester (4E)-TCO-PEG4-DBCO (4E)-TCO-amine TCO-PEG4-Acid BDP FL-PEG4-(4E)-TCO trans-Cyclooctene-maleimide Sulfo-Cy5-(4E)-TCO (4E)-TCO-PEG4-amine TCO-PEG3-Amine TCO-carbonate TCO/E- active ester (p-NPE) / equatorial