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FD-IN-1

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FD-IN-1 Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:(S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid
CAS:1646682-14-5
Package:100g,1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:FD-IN-1
CAS:1646682-14-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:FD-IN-1
CAS:1646682-14-5
Purity:99% Package:$350.9/5mg;$580.9/10mg;$1100.9/25mg;$1700.9/50mg;$2500.9/100mg;Bulk package Remarks:99%
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Products Intro: Product Name:FD-IN-1
CAS:1646682-14-5
Company Name: Yujinpharma(Tianjin) Technology Co.,Ltd.  
Tel: 13370351217 kungfu1217@1
Email: kungfu1217@163.com
Products Intro: CAS:1646682-14-5
FD-IN-1 Basic information
Product Name:FD-IN-1
Synonyms:FD-IN-1;Benzeneacetic acid, 2-[[3'-[(1S)-1-amino-2-hydroxyethyl][1,1'-biphenyl]-3-yl]methoxy]-;(S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid;FDIN1,FD IN 1;(S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid
CAS:1646682-14-5
MF:C23H23NO4
MW:377.43
EINECS:
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Mol File:1646682-14-5.mol
FD-IN-1 Structure
FD-IN-1 Chemical Properties
Boiling point 629.4±55.0 °C(Predicted)
density 1.251±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka4.14±0.10(Predicted)
Safety Information
MSDS Information
FD-IN-1 Usage And Synthesis
Biological ActivityFD-IN-1 (Compound 12) is a potent, orally active complement factor D (FD) inhibitor with IC50 of 12 nM.It also inhibits factor XIa (FXIa) and tryptase β2 with IC50 of 7.7 and 6.5 μM, respectively.
in vitro

FD-IN-1 (Compound 12) exhibits functional inhibition of AP activation (IC 50 =0.26 μM) in vitro in a membrane attack complex (MAC) deposition assay using 50% human whole blood (WB).

in vivo

FD-IN-1 (Compound 12) demonstrates systemic suppression of AP activation in a lipopolysaccharide-induced alternative complement pathway (AP) activation model as well as local ocular suppression in intravitreal injection-induced AP activation model in mice expressing human FD.
FD-IN-1 (Compound 12) exhibits high oral bioavailability (C57BL6 mice 83%, Beagle dogs 70%) following oral administration (mice and dogs 10 mg/kg).
FD -IN-1 (Compound 12) exhibits terminal elimination half-lives (C57BL6 mice 1.6 h and Beagle dogs 3.8 h) following intravenous administration (mice and dogs 1 mg/kg).

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Animal Model: Human FD knock-in mice
Dosage: 3 and 10 mg/kg
Administration: Oral gavage
Result: The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose.
FD-IN-1 Preparation Products And Raw materials
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