Pazufloxacin
Price | $2 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 100kg |
Update Time: | 2019-07-06 |
Product Details
Product Name: Pazufloxacin | CAS No.: 127045-41-4 |
Min. Order: 1kg | Purity: 98% |
Supply Ability: 100kg | Release date: 2019/07/06 |
Product Number:: wm1024 |
Pazufloxacin Basic information |
Description References |
Product Name: | Pazufloxacin |
Synonyms: | PAZUFLOXAXIN;T-3761;(s)-yclopropyl)-9-fluoro-3-methyl-7-oxo;Pazufloxacinmyesylate;(3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID;ALKALYL;Pazufloxaxin mesilate;PAZUFLOXACIN 98+% |
CAS: | 127045-41-4 |
MF: | C16H15FN2O4 |
MW: | 318.3 |
EINECS: | 1806241-263-5 |
Product Categories: | BacteriostaticAntibiotics;ChinolonesAlphabetic;PA - PENAnalytical Standards;Pharmacology Standards;Antibiotics;Chemical Structure;Chromatography;P;Principle;API's |
Mol File: | 127045-41-4.mol |
Pazufloxacin Chemical Properties |
Melting point | 269-271°C |
alpha | D25 -88.0° (c = 0.5 in 0.05N aq NaOH) |
density | 1.56 |
storage temp. | 2-8°C |
CAS DataBase Reference | 127045-41-4(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn,C,F |
Risk Statements | 20/21/22-34-11 |
Safety Statements | 36/37-45-36/37/39-26-16 |
RTECS | UU8815300 |
Toxicity | LD50 i.v. in male mice: >500 mg/kg (Todo) |
MSDS Information |
Provider | Language |
---|---|
(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid | English |
Pazufloxacin Usage And Synthesis |
Description | Pazufloxacin is a fluoroquinolone with a 1-aminocyclopropyl substituent at C10 position. The presence of aminoacyl group at C-10 is a unique feature of the molecule imparting potent broad spectrum activity against gram-positive and gram-negative bacteria. This activity is based on the inhibition of bacterial DNA gyrase. Pazufloxacin is used as an injectable antibiotic with bacterial effect against cephalosporin-resistant, carbapenem-resistance, and aminoglycoside resistant strains of bacteria. The adverse effects of pazufloxacin, such as drug-induced convulsion and hypotension are less than those of other conventional injectable fluoroquinolones. |
References | [1] A. Vora, Pazufloxacin, tracked from www.japi.org on 16.07.2017 [2] Jeffrey K. Aronson, Meyler’s Side Effects of Antimicrobial Drugs, 2009 [3] Satoshi Watabe, Yoshiaki Yokoyama, Kazuyuki Nakazawa, Kimikazu Shinozaki, Rika Hiraoka, Kei Takeshita and Yukio Suzuki, Simultaneous measurement of pazufloxacin, ciprofloxacin, and levofloxacin in human serum by high-performance liquid chromatography with fluorescence detection, Journal of Chromatography B, 2010, vol. 878, 1555-1561 |
Uses | antibactierial |
Pazufloxacin Preparation Products And Raw materials |
Raw materials | Ethyl acetate-->Trifluoroacetic acid-->Sodium sulfite-->Sodium azide-->Paraformaldehyde-->N,N-Dimethylformamide dimethyl acetal-->Dimethyl sulfide-->Methanesulfonic acid-->1,1'-Carbonyldiimidazole-->5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide-->Diphenyldiazomethane-->Ethyl 2,3,4,5-tetrafluorobenzoate-->Di-tert-Butyl malonate |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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杨俊青
15093356674
sales@coreychem.com
15093356674
sales@coreychem.com