Dorzolamide

Dorzolamide Basic information
Product Name: Dorzolamide
Synonyms: (2r,4r)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide;DORZOLAMIDE;DORZOLAMIDE(SUBJECTTOPATENTFREE);4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-;4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-;4S,6S-Dorzolamide;(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,;Dorzalamide hydrochloride
CAS: 120279-96-1
MF: C10H16N2O4S3
MW: 324.44
EINECS: 1533716-785-6
Product Categories:
Mol File: 120279-96-1.mol
Dorzolamide Structure
Dorzolamide Chemical Properties
Boiling point 575.8±60.0 °C(Predicted)
density 1.53±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble5mg/mL (clear solution, warmed)
pka pKa 6.35 (Uncertain);8.50 (Uncertain)
form powder
color white to beige
optical activity [α]/D -25 to -35°, c = 1 in methanol
CAS DataBase Reference 120279-96-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
RTECS XJ9095169
MSDS Information
Dorzolamide Usage And Synthesis
Uses Carbonic anhydrase inhibitor.
Definition ChEBI: 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration . A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Brand name Trusopt (Merck).
Dorzolamide Preparation Products And Raw materials