Mitomycin C NEW

Mitomycin C is a broad-spectrum anti-tumor antibiotic extracted from Streptomyces bacteria. It has genotoxicity and anti-tumor properties. It is a universally recognized inhibitor of DNA damage and has anticancer effect on a variety of cancers. Selective inhibition of DNA, cellular RNA and protein synthesis, thereby inhibiting tumor cell division.

Mitomycin C is a non-specific cell cycle drug with a broad anti-tumor spectrum and rapid action, but its therapeutic index is not high and its toxicity is high. It is clinically suitable for digestive tract cancer, such as gastric cancer, bowel cancer, liver cancer and pancreatic cancer. It is also effective for lung cancer, breast cancer, cervical cancer and chorionic epithelial cancer. It can also be used for malignant lymphoma, cancerous chest and abdominal effusion. Mitomycin C is also a chemical mutagenic agent that can cause DNA mutation. Saffron extract can significantly inhibit the reproductive toxicity of anticancer drugs such as cisplatin, cyclophosphamide, mitomycin C and ethyl carbamate, and the size of the inhibition effect is not significantly related to the dose. It can be predicted that the use of saffron in combination with other anticancer drugs is expected to reduce the toxic side effects of these anticancer drugs.

Application:

1 Cell division inhibitors, nucleic acid inhibitors and phage inducers; Clinical use as an antitumor drug.

2. The product has a wide anti-tumor spectrum and has good effect on gastric cancer and breast cancer. It has some effect on lung cancer, liver cancer, malignant lymphoma, Hodgkin's disease, reticular cell sarcoma, uterine cancer, leukemia, intestinal cancer and pancreatic cancer, but the remission period is short. Combined with urokinase can improve the curative effect, the effect of the product is rapid, but the number of treatment operators is not high, the toxicity is large. This product and bleomycin and its derivative pylemycin are DNA-damaging antibiotic anticancer drugs, which can depolymerize cell DNA and inhibit DNA replication in proliferative cells. The LD50 for intravenous injection in mice was 5ml/kg.

3 Anti-cancer drugs, often used to treat cancers of the digestive system