Propargyl-PEG4-acid NEW
| Price | $5 | $0.1 |
| Package | 1KG | 1000KG |
| Min. Order: | 1KG |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-03-27 |
Product Details
| Product Name: Propargyl-PEG4-acid | CAS No.: 1415800-32-6 |
| Min. Order: 1KG | Purity: 98% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/03/27 |
| Lead time: In stock, ready for shipment | Packaging: bag/bottle/drum/IBC |
| Delivery: By express, by air, by sea | Origin: Manufacturer, advantage product |
| COA, MSDS: Available, contact us for details | Name: Tina |
1. Materials information
| Name | 4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. |
|---|---|
| Related Catalog | Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker |
| Target | PEGs |
| In Vitro | BTK-IAP PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of IAP E3 ligases family recruitment[1]. |
| References | [1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 388.0±37.0 °C at 760 mmHg |
| Molecular Formula | C12H20O6 |
| Molecular Weight | 260.284 |
| Flash Point | 141.0±20.0 °C |
| Exact Mass | 260.125977 |
| LogP | -0.80 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.468 |
| Hazard Codes | Xi |
|---|
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: Tina@fdachem.com
Mob: 86 15225627621
WhatsApp/Skype/Wechat/LINE: 86 15225627621
Company Profile Introduction
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Career Henan Chemical Co
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2020-03-23 |
China
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro