Tetrazolium Violet NEW

Price	$6	$5	$1
Package	1KG	25KG	100KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-29

Product Details

Product Name: Tetrazolium Violet	CAS No.: 1719-71-7
Min. Order: 1KG	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/29
Lead time: In stock	Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express	Origin: Manufacturer
Name: Sun

1. Product information

Name	ledipasvir
Synonym	More Synonyms

Description	Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC50: 34 pM (GT1a), 4 pM (GT1b)[1]
In Vitro	Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].
In Vivo	Ledipasvir is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey and low predicted clearance in human. The pharmacokinetics of Ledipasvir is measured in rats and dogs. Ledipasvir shows good half-lives (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume[1].
Animal Admin	Rats, Dogs and Monkeys[1] Pharmacokinetic studies are performed in male naı̈ve Sprague-Dawley(SD) rats, non-naive beagle dogs, and cynomolgus monkeys (three animals per dosing route). Intravenous (IV) administration is dosed via infusion over 30 min in a vehicle containing 5% ethanol, 20% PEG400, and 75% water (pH adjusted to 3.0 with HCl). Oral dosing is administered by gavage in a vehicle containing 5% ethanol, 45% PEG 400, and 50% of 50 mM citrate buffer, pH 3. Blood samples are collected over a 24 h period postdose into Vacutainer tubes containing EDTA-K2. Plasma was isolated, and the concentration of the test compound in plasma was determined with LC/MS/MS after protein precipitation with acetonitrile.
References	[1]. Link JO, et al. Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46 [2]. Hernandez D, et al. Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors. J Clin Virol. 2013 May;57(1):13-8.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₉H₅₄F₂N₈O₆
Molecular Weight	889.000
Exact Mass	888.413452
PSA	174.64000
LogP	6.77
Index of Refraction	1.677

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	3077
HS Code	29333990

Name	tetrazolium violet
Synonym	More Synonyms

Description	Tetrazolium Violet is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others

Melting Point	245-250 °C (dec.)
Molecular Formula	C₂₃H₁₇ClN₄
Molecular Weight	349.407
Exact Mass	349.144775
PSA	34.59000
LogP	1.36820
Storage condition	Flammables area

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XF8080000

CHEMICAL NAME :
2H-Tetrazolium, 3-(1-naphthyl)-2,5-diphenyl-, chloride

CAS REGISTRY NUMBER :
1719-71-7

LAST UPDATED :
199409

DATA ITEMS CITED :
1

MOLECULAR FORMULA :
C23-H17-N4.Cl

MOLECULAR WEIGHT :
384.89

WISWESSER LINE NOTATION :
T5NKNNJ CR& ER& B- BL66J &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA adduct

TEST SYSTEM :
Bacteria - Escherichia coli

DOSE/DURATION :
10 mg/L

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;F: Flammable;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26-S16
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XF8080000

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2-naphthalen-1-yl-3,5-diphenyltetrazol-2-ium,chloride

Violet Tetrazolium

EINECS 217-008-7

MFCD00011875

Tetrazolium Violet

2,5-Diphenyl-3-(1-Naphthyl)Tetrazolium Chloride

2H-Tetrazolium, 3-(1-naphthalenyl)-2,5-diphenyl-

3-(1-Naphthyl)-2,5-diphenyl-2H-tetrazol-3-ium

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

Article illustration

3. Shipping

Article illustration

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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Henan Fengda Chemical Co., Ltd

1YR

China

Since: 2023-02-10
Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Tetrazolium Violet NEW

Product Details

Names

Ledipasvir Biological Activity

Chemical & Physical Properties

Safety Information

Names

Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information