|
Metabolic system
|
代谢系统
|
|
|
Screening model of gastrointestinal motility inhibitors
|
胃肠动力抑制剂筛选模型
|
|
|
Myocardial injury protective agent screening model
|
心肌损伤保护剂筛选模型
|
|
|
Screening model of renal protective agents
|
肾功能保护剂筛选模型
|
|
|
Reproductive toxicity and reproductive ability evaluation; Gonadal growth evaluation; Histological sections of gonads;
|
生殖毒性生殖能力评价;性腺生长评价;性腺病理组织切片;
|
|
|
Gastrointestinal peristalsis function (autonomic nerve).
|
胃肠蠕动功能（植物神经）。
|
|
|
inflammatory reaction
|
炎症反应
|
|
|
Intestinal morphology; Intestinal peristalsis requires motor function.
|
肠道形态学;肠蠕需动功能。
|
|
|
Carry out appropriate toxicity tests with experimental animals
|
用实验动物进行适当的毒性试验
|
|
|
Genetically modified animal model
|
遗传修饰动物模型
|
|
|
Apoptosis inhibitor screening model
|
凋亡抑制剂筛选模型
|
|
|
Fat metabolism model
|
脂肪代谢模型
|
|
|
Erythrocyte thrombosis model
|
红细胞性血栓模型
|
|
|
Mouse bradycardia model
|
小鼠心动过缓模型
|
|
|
Incidence of developmental toxicity and teratogenicity (brain, jaw, eye, kidney, intestine, trunk / tail / spinal cord / somite, body coloring, circulatory system, body edema, bleeding)
|
发育毒性与致畸性（脑、下颚、眼、肾脏、肠道、躯干/尾/脊髓/体节、身体着色、循环系统、身体水肿、出血）毒性发生率
|
|
|
Behavior (touch response, movement influence, light and dark influence);
|
行为学（触碰反应、运动影响、光暗影响）;
|
|
|
Behavior
|
行为学
|
|
|
Anaphylactic reaction
|
类过敏反应
|
|
|
Animal model of depression
|
抑郁动物模型
|
|
|
neurotoxicity
|
神经毒性
|
|
|
Immunotoxicity
|
免疫毒性
|
|
|
Preclinical drug experiment preclinical research (outsourcing entrusted experiment)
|
药物临床前实验 临床前研究（外包委托实验）
|
|
|
Efficacy evaluation model of drug efficacy evaluation system
|
药物功效评价 系统 功效评价模型
|
|
|
Mitochondrial function
|
线粒体功能
|
|
|
Protective model of vascular endothelial injury
|
血管内皮损伤保护模型
|
|
|
Promoting tissue regeneration / wound healing
|
促组织再生作用/伤口愈合
|
|
|
Embryotoxicity (OECD standard)
|
胚胎毒性（OECD标准）
|
|
|
Degree of liver degeneration; Yolk sac size.
|
肝变性程度;卵黄囊大小。
|
|
|
Osteotoxicity
|
骨毒性
|
|
|
Phenotypic observation
|
表型观察
|
|
|
Induction model of high sugar and high fat diet
|
高糖高脂饮食诱导模型
|
|
|
Screening model of antialcoholic agents
|
解酒剂筛选模型
|
|
|
Screening model of angiogenesis promoters
|
血管再生促进剂筛选模型
|
|
|
Cytochrome P450 analysis
|
细胞色素P450分析
|
|
|
Cartilage injury model
|
软骨损伤模型
|
|
|
apoptotic cell
|
凋亡细胞
|
|
|
The incidence of renal capsule edema;.
|
肾包膜水肿发生率;。
|
|
|
Ocular toxicity
|
眼毒性
|
|
|
Mortality; Evaluation of median lethal concentration (LC50).
|
死亡率;半数致死浓度（LC50）评价。
|
|
|
Screening model of P-glycoprotein inhibitors
|
P-糖蛋白抑制剂筛选模型
|
|
|
Screening model of energy metabolism regulator
|
能量代谢调节剂筛选模型
|
|
|
Induced qi stagnation and blood stasis thrombosis model
|
诱导气滞血瘀型血栓模型
|
|
|
Liver kidney model
|
肝肾模型
|
|
|
Cardiovascular toxicity heart rate; Heart rhythm; The incidence of pericardial edema; Incidence of bleeding; Incidence of changes in blood flow velocity; Incidence of thrombosis
|
心血管毒性心率;心律;心包水肿发生率;出血发生率;血流速度变化的发生率;血栓发生率
|
|
|
Fluorescence signal intensity of apoptotic cells in central nervous system;
|
中枢神经凋亡细胞荧光信号强度;
|
|
|
Carcinogenicity (mice)
|
致癌性（小鼠）
|
|
|
Tryptase expression level (OD value); Anaphylactic reaction test.
|
Tryptase表达水平（OD值）;类过敏反应检测。
|
|
|
Animal experiment of depression
|
抑郁动物实验
|
|
|
Preclinical evaluation of cardiac drugs
|
心脏药物临床前评价
|
|
|
Anti angiogenesis model
|
抗血管形成模型
|
|
|
Cardio cerebrovascular
|
心脑血管
|
|
|
PM2. 5. Screening model of drainage promoters
|
PM2.5促排剂筛选模型
|
|
|
Screening model of bone development promoters
|
骨骼发育促进剂筛选模型
|
|
|
The incidence of egg coagulation; No heart rate; Hatching rate; The incidence of no somite formation; Incidence of tail non separation;
|
卵凝结发生率;无心跳发生率;孵化率;体节未形成发生率;尾部未分离发生率;
|
|
|
Nephrotoxicity
|
肾毒性
|
|
|
Bone mineral density (fluorescence signal intensity); Number of vertebrae.
|
骨密度（荧光信号强度）;脊椎骨数量。
|
|
|
Median lethal concentration
|
半数致死浓度
|
|
|
Should we experiment with animals
|
应该用动物做实验吗
|
|
|
Skin irritation; Muscle texture; Quantification of skin apoptotic cells; Skin pigment changes.
|
皮肤刺激;肌肉纹理;皮肤凋亡细胞定量;皮肤色素变化。
|
|
|
Safety evaluation
|
安全性评价
|
|
|
Preclinical evaluation of antiviral research and development
|
抗病毒研发临床前评价
|
|
|
Uric acid model
|
尿酸模型
|
|
|
Intestinal digestive function
|
肠道消化功能
|
|
|
Skeletal muscle
|
骨骼肌肉
|
|
|
Screening model of therapeutic agents for osteoporosis
|
骨质疏松症治疗剂筛选模型
|
|
|
Fluorescence signal intensity of apoptotic cells (AO staining, TUNEL staining)
|
凋亡细胞荧光信号强度（AO染色、TUNEL染色）
|
|
|
Audiotoxicity
|
听毒性
|
|
|
Eye size; Ocular apoptotic cells; Ocular vascular area; Ocular histopathology.
|
眼睛大小;眼部凋亡细胞;眼部血管面积;眼组织病理学。
|
|
|
Genotoxicity
|
基因毒性
|
|
|
Induction model of caspase activity
|
对Caspase活性的诱导作用模型
|
|
|
Pharmacodynamic evaluation model of slimming drugs
|
减肥药药效评价模型
|
|
|
Drug screening model for the treatment of heart failure
|
心衰治疗药物筛选模型
|
|
|
Screening model of hepatoprotective drugs
|
保肝药筛选模型
|
|
|
Number of hematotoxic neutrophils; Number of macrophages; Number of red blood cells (signal intensity); Blood flow.
|
血液毒性中性粒细胞数量;巨噬细胞数量;红细胞数量（信号强度）;血流量。
|
|
|
Peripheral motor nerve length; Incidence of brain degeneration;
|
周围运动神经长度;脑变性发生率;
|
|
|
Macrophage function
|
巨噬细胞功能
|
|
|
Gastrointestinal toxicity
|
胃肠道毒性
|
|
|
Why do experiments with animals
|
用动物做实验的原因
|
|
|
Genetic engineering animal model
|
遗传工程动物模型
|
|
|
mycoalert mycoplasma detection kit
|
支原体检测试剂盒
|
|
|
Preclinical spinal cord injury experiment
|
临床前脊髓损伤实验
|
|
|
Angiogenesis inhibitor screening
|
血管形成抑制剂筛选
|
|
|
Hypolipidemic model
|
降血脂模型
|
|
|
Platelet aggregation thrombosis model
|
血小板聚集性血栓模型
|
|
|
Oxygen free radical (ROS) scavenger screening model
|
氧自由基（ROs）清除剂筛选模型
|
|
|
Incidence of acute toxicity (brain, jaw, eye, kidney, intestine, trunk / tail / spinal cord / somite, body coloring, circulatory system, body edema, bleeding)
|
急性毒性（脑、下颚、眼、肾脏、肠道、躯干/尾/脊髓/体节、身体着色、循环系统、身体水肿、出血）毒性发生率
|
|
|
Vitellogenin (VTG) content detection; The expression of genes related to hypothalamic pituitary gonadal axis was detected.
|
卵黄蛋白原（VTG）含量检测;下丘脑-垂体-性腺 轴线相关基因表达量检测。
|
|
|
Behavioral toxicity
|
行为毒性
|
|
|
Number of neutrophils; Expression level of inflammatory factors.
|
中性粒细胞数量;炎症因子表达水平。
|
|
|
Factors affecting animal models
|
影响动物模型的因素
|
|
|
Drug evaluation and testing items (outsourcing entrusted experiment)
|
药物评价检测项目（外包委托实验）
|
|
|
Preclinical evaluation of reproductive toxicity
|
生殖毒临床前评价
|
|
|
Spleen yang deficiency model
|
脾阳虚模型
|
|
|
Intestinal mucus secretion function
|
肠道粘液分泌功能
|
|
|
Analgesic drug screening
|
镇痛药物筛选
|
|
|
Drug safety evaluation model index
|
药物安全性评价 评价模型 指标
|
|
|
Hepatotoxicity (juvenile fish)
|
肝毒性（幼鱼）
|
|
|
Fluorescence signal intensity of hair cells
|
毛细胞荧光信号强度
|
|
|
Skin toxicity
|
皮肤毒性
|
|
|
Comet experiment; Genotoxicity evaluation.
|
慧星实验;基因毒性评价。
|
|