产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Hexylresorcinol | 100mg 500mg | 136-77-6 | EY-Y0164515 |
Cas No.136-77-6
别名
化学名 4-hexylbenzene-1,3-diol
分子式 C12H18O2
分子量 194.27
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
IC50: 1.24 μM
Hexylresorcinol is a mushroom tyrosinase inhibitor.
Tyrosinase, a copper-containing enzyme, is distributed in microorganisms, animals, and plants widely. Mushroom tyrosinase has been becoming popular due to its availability and usages in various applications.
In vitro: Previous results showed hexylresorcinol could inhibit both mono- and di-phenolase activity of mushroom tyrosinase. Moreover, hexylresorcinol at 2 μM lengthened the lag period from 98 s to 26. Hexylresorcinol could also display reversible inhibition of the enzyme. In addition, the kinetic analyses showed that hexylresorcinol was a competitive inhibitor with the apparent inhibition constant binding with free enzyme to be 0.443 μM for diphenolase [1].
In vivo: Previous in vivo study showed that hexylresorcinol could induce chromosome aberrations in mouse eukaryotic cells at doses of 0.5, 0.05, and 0.005 mg/g and the metabolic transformation of hexylresorcinol decreased its genotoxic effect in mice. Moreover, the mutagenic effect lasted for 3 days only at the highest dose of hexylresorcinol (0.5 mg/g). Thus, hexylresorcinol doses less than 0.5 mg/g were metabolized within two days to the extent of the cytotoxic effect. In addition, hexylresorcinol was transformed at a rate of 0.0025–0.025 mg/day after a single administration to mice [2].
Clinical trial: Hexylresorcinol is clinically available for topically use on small skin infections, or as an ingredient in throat lozenges. Johnson & Johnson has marketed hexylresorcinol in its skincare products as an anti-aging cream (https://en.wikipedia.org/wiki/Hexylresorcinol).
References:
[1] Chen QX,Ke LN,Song KK,Huang H,Liu XD. Inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (Agaricus bisporus) tyrosinase. Protein J.2004 Feb;23(2):135-41.
[2] Margulis AB,Ozhiganova IV,Bushmanova OV,Kolpakov AI,Il'inskaia ON. Hexylresorcinol induces chromosome aberrations in mouse peripheral blood cells. Genetika. 2005 Aug;41(8):1045-8.
关键字： 136-77-6;C12H18O2;Hexylresorcinol;
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