Diazomethane

Carcinogenicity, Category 1B

H350 May cause cancer

P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention . Wear protective gloves when administering first aid.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Unlikely under occupational conditions.

Exposure Routes: inhalation, skin and/or eye contact (liquid) Symptoms: Irritation eyes; cough, shortness breath; headache, lassitude (weakness, exhaustion); flush skin, fever; chest pain, pulmonary edema, pneumonitis; asthma; liquid: frostbite Target Organs: Eyes, respiratory system (NIOSH, 2016)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

If material /is/ on fire or involved in /a/ fire use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]: Flammable; may be ignited by heat, sparks or flames. May form explosive mixtures with air. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Vapors from liquefied gas are initially heavier than air and spread along ground. Vapors may travel to source of ignition and flash back. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. Runoff may create fire or explosion hazard. (ERG, 2016)

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. Combat fire from a sheltered position.

Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.

Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.

In the event of a spill or leak involving diazomethane, persons not wearing protective equipment and clothing should be restricted from contaminated areas until cleanup has been completed. The following steps should be undertaken following a spill or leak: Notify safety personnel. Remove all sources of heat and ignition. Ventilate potentially explosive atmospheres. Provide and require the use of fully-encapsulating, vapor-protective clothing and equipment for cleanup personnel. If possible without risk, stop flow of gas. If source of leak is a cylinder and cannot be stopped in place, remove the leaking cylinder to a safe place in the open air, and repair leak or allow cylinder to empty. If the leak is in the liquid form, allow diazomethane to evaporate.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Solutions of diazomethane should not be stored. See Notes.Diazomethane should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard. Containers of diazomethane should be protected from shock, heat, sparks, open flames and physical damage and should be stored separately from alkali metals, calcium sulfate, calcium chloride, boiling stones, or copper powder. Outside or detached storage is preferred. Empty containers of diazomethane should be handled appropriately.

TLV: 0.2 ppm as TWA; A2 (suspected human carcinogen).MAK: carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Cold-insulating gloves.

Use ventilation, local exhaust or breathing protection.

no data available

May decompose explosively on shock, friction or concussion. May explode on heating at 100°C or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosion.

no data available

The gas is heavier than air and may travel along the ground; distant ignition possible.DIAZOMETHANE undergoes violent thermal decomposition. Above 200°C. the vapors may explode violently if rough glass surfaces are present. Explosions at low temperatures can occur if traces of organic matter are present. [J. Phys. Chem. 35:1403(1931)]. Produces explosions with alkali metals. Reacts with copper powder and to some extent all solid surfaces to produce nitrogen and solid white polymethylene. Reacts with dimethylaminodimethylarsine and trimethyltin in ether with vigorous foaming.

no data available

Contact between diazomethane and alkali metals, calcium sulfate, calcium chloride, boiling stones, or copper powder will cause explosions.

When heated to decomposition ... emits highly toxic fumes of /nitrogen oxides./ srp: diazomethane does not need to decompose to emit toxic fumes.

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No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

No information is available on the reproductive or developmental effects of diazomethane in humans or animals.

The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthma-like reactions (RADS). See Notes. The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated.

Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Diazomethane is a gas and reacts rapidly with water; therefore biodegradation is not expected to be an important environmental fate process. (SRC)

Diazomethane is a gas and undergoes rapid hydrolysis with water; therefore, bioconcentration is not expected to be an important environmental fate process. (SRC)

Diazomethane is a gas and undergoes rapid hydrolysis with water; therefore, adsorption is not expected to be an important environmental fate process. (SRC)

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.The relation between odour and the occupational exposure limit cannot be indicated.The recommendations on this Card also apply to concentrated solutions of diazomethane.