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ChemicalBook >> CAS DataBase List >> tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate price.
  • $7 - $1283
  • Product name: tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
  • CAS: 365998-36-3
  • MF: C14H27N3O3
  • MW: 285.38
  • EINECS:1592732-453-0
  • MDL Number:MFCD22190570
  • Synonyms:Edoxaban INTERMEDIATES Ⅱ;Edoxaban INTERMEDIATES Ⅲ;InterMediate of Edoxaban;Tert-Butyl [(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]carbaMate(for Edoxaban);Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester, ethanedioate (1:1);N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl] -, 1,1-dimethylethyl ester;D-1315;(5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester
Price14 Properties Safety Information Description
14 prices
Selected condition：
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • Chemenu
  • Crysdot
  • SynQuest Laboratories
  • TRC
Package
  • 5MG
  • 250mg
  • 1g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAmbeed
  • Product numberA281254
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95%
  • Packaging250mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA281254
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95%
  • Packaging1g
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA281254
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95%
  • Packaging5g
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA281254
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95%
  • Packaging25g
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA281254
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95%
  • Packaging100g
  • Price$414
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0065742
  • Product descriptionTERT-BUTYL N-[(1R,2S,5S)-2-AMINO-5-(DIMETHYLCARBAMOYL)CYCLOHEXYL]CARBAMATE 95.00%
  • Packaging5MG
  • Price$458.62
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM107869
  • Product descriptiontert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97%
  • Packaging5g
  • Price$253
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM107869
  • Product descriptiontert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97%
  • Packaging10g
  • Price$418
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13014552
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95+%
  • Packaging5g
  • Price$770
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13014552
  • Product descriptiontert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95+%
  • Packaging10g
  • Price$1283
  • Updated2021-12-16
  • Buy
  • ManufacturerSynQuest Laboratories
  • Product number4256-1-70
  • Product descriptiontert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0%
  • Packaging250mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerSynQuest Laboratories
  • Product number4256-1-70
  • Product descriptiontert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0%
  • Packaging1g
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerSynQuest Laboratories
  • Product number4256-1-70
  • Product descriptiontert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0%
  • Packaging5G
  • Price$790
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB809495
  • Product descriptiontert-Butyl[(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
  • Packaging1g
  • Price$250
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A281254 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95% 250mg $7 2021-12-16 Buy
Ambeed A281254 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95% 1g $15 2021-12-16 Buy
Ambeed A281254 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95% 5g $42 2021-12-16 Buy
Ambeed A281254 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95% 25g $138 2021-12-16 Buy
Ambeed A281254 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95% 100g $414 2021-12-16 Buy
American Custom Chemicals Corporation CCH0065742 TERT-BUTYL N-[(1R,2S,5S)-2-AMINO-5-(DIMETHYLCARBAMOYL)CYCLOHEXYL]CARBAMATE 95.00% 5MG $458.62 2021-12-16 Buy
Chemenu CM107869 tert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97% 5g $253 2021-12-16 Buy
Chemenu CM107869 tert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97% 10g $418 2021-12-16 Buy
Crysdot CD13014552 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95+% 5g $770 2021-12-16 Buy
Crysdot CD13014552 tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 95+% 10g $1283 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 250mg $190 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 1g $490 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 5G $790 2021-12-16 Buy
TRC B809495 tert-Butyl[(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate 1g $250 2021-12-16 Buy

Properties

Boiling point :434.4±45.0 °C(Predicted)
Density :1.09±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
form :Solid
pka :11.90±0.60(Predicted)
CAS DataBase Reference :365998-36-3

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310 Immediately call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P361 Remove/Take off immediately all contaminated clothing.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tert-butyl(1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is an organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. It is a reagent used in the synthesis of cis-1,2-diaminocyclohexane derivative. It is also mainly used as raw material to synthesize reversible factor Xa inhibitor drug edoxaban[1]. The drug has been approved by the U.S. Food and Drug Administration as a direct oral anticoagulant and is the fourth direct oral anticoagulant approved for clinical use[2-3].

Referance：[1] Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan, Jan Stasko, Edoxaban affects TRAP-dependent platelet aggregation, Journal of Thrombosis and Thrombolysis, 2020, 49, 578-583.
[2] Juraj Sokol, Frantisek Nehaj, Jela Ivankova, Michal Mokan, Lenka Lisa, Jana Zolkova, Lubica Vadelova, Marian Mokan, Jan Stasko, Impact of Edoxaban on Thrombin-Dependent Platelet Aggregation,Clinical and Applied Thrombosis/Hemostasis, 2020.
[3] Mara Poulakos, Jacqueline N Walker, Umima Baig, Tosin David, Edoxaban: A direct oral anticoagulant, American Journal of Health-System Pharmacy, 2017,74, 117–129.

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Suppliers and manufacturers

Zhuhai Hairuide Bioscience and Technology Co., Ltd
Tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethyl carbamoyl) cyclohexyl) carbamate
$0.00 /1KG Ton
Tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethyl carbamoyl) cyclohexyl) carbamate CAS:365998-36-3
Anhui Ruihan Technology Co., Ltd
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
$30.00 /1kg
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate CAS:365998-36-3
career henan chemical co
(5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester
$1.00 /1kg
(5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester CAS:365998-36-3
Eaglech（shanghai）Pharmaceutical Co., Ltd
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Shanghai Time Chemicals CO., Ltd.
SHANDONG ZHI SHANG CHEMICAL CO.LTD
Jinan Carbotang Biotech Co.,Ltd.
HubeiwidelychemicaltechnologyCo.,Ltd