1-(2,4-Dimethylphenyl)piperazine synthesis

Yield:-

Reaction Conditions:

with potassium iodide at 150;Inert atmosphere;

Steps:

4.1. General procedure for the synthesis of piperazine derivatives 3a-w

General procedure: In a flask charged with diethylene glycol monomethyl ether (8 mL)added equimolar quantities (25 mmol) of appropriate amine (1a-w)and bis(2-chloroethyl)amine hydrochloride (2). The resulting mixturewas heated for 150 °C for 16-48 h under N2 atmosphere in the presenceof catalytic amount of KI (3 mol%). The progress of the reaction wasmonitored using TLC with the mobile phase toluene: acetone (8:2).After the completion of the reaction, the mixture was cooled to roomtemperature and dissolved in methanol (25 mL), and ethyl acetate(100 mL) was added. The precipitate thus obtained were filtered,washed with ethyl acetate and the resulting salt was then convertedto free amines upon treating with Na2CO3 and extracted with ethyl acetate(2 × 25 mL). The combined organic phase was dried over MgSO4and evaporated to give analytically pure piperazine derivatives 3a-win reasonably good yields.

References:

Patel, Rahul V.;Mistry, Bhupendra;Syed, Riyaz;Rathi, Anuj K.;Lee, Yoo-Jung;Sung, Jung-Suk;Shinf, Han-Seung;Keum, Young-Soo [European Journal of Pharmaceutical Sciences,2016,vol. 88,p. 166 - 177]