ChemicalBook CAS DataBase List 1-(4-CHLOROBENZYL)PIPERAZINE

1-(4-CHLOROBENZYL)PIPERAZINE synthesis

11synthesis methods

Product Name:1-(4-CHLOROBENZYL)PIPERAZINE
CAS Number:23145-88-2
Molecular formula:C11H15ClN2
Molecular Weight:210.7

ETHYL2-CHLORO-8-EHTYL-5,8-DIHYDRO-5-OXOPYRIDO(2,3-D)PYRIMUIDINE-6-CARBOXYLATE

51940-33-1
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23145-88-2
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Yield: 74%

Steps:

XV 2-(4'-p-Chlorobenzyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid. SPC22
EXAMPLE XV 2-(4'-p-Chlorobenzyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid. SPC22 Condensation of 1-p-chlorobenzyl-piperazine with 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine, as described in Example VII, gives, in a yield of 74%, 2-(4'-p-chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine; melting point 150°C, after recrystallisation from ethyl acetate. Analysis for C₂₃ H₂₆ ClN₅ O₃ (molecular weight 455.5): Calculated %: C, 60.59; H, 5.70; N, 15.36; Cl, 7.79. Found %: C, 60.29; H, 5.72; N, 15.38; Cl, 7.76.

References:

Laboratoire Roger Bellon US3950338, 1976, A

110-85-0 Synthesis