ChemicalBook CAS DataBase List 1-(4-Methylphenyl)ethanol

1-(4-Methylphenyl)ethanol synthesis

11synthesis methods

Product Name:1-(4-Methylphenyl)ethanol
CAS Number:536-50-5
Molecular formula:C9H12O
Molecular Weight:136.19

From p-tolymagnesium bromide and acetaldehyde in ether; from 4-methylaceto-phenone with sodium metal in ethanol

622-96-8 Synthesis

622-96-8
160 suppliers
$28.39/5g

536-50-5
106 suppliers
$29.00/1g

Yield:536-50-5 93%

Reaction Conditions:

with C₂₂H₃₀B₁₀Cl₂FeN₆O₂;dihydrogen peroxide in methanol at 20; for 7 h;

Steps:

10

4-methylethylbenzene (1.0 mmol), iron complex 2 (0.05 mmol) and H2O2 (1.3 mmol) were dissolved in 2 mL of methanol and reacted at room temperature for 7 hours. After the reaction was completed, the reaction solution was concentrated and separated directly by silica gel column chromatography. Drying to the same mass yields the corresponding product C9H12O (93% yield).

References:

CN110627841,2019,A Location in patent:Paragraph 0069-0072

622-97-9 Synthesis