N,N-Diethylpropargylamine synthesis
- Product Name:N,N-Diethylpropargylamine
- CAS Number:4079-68-9
- Molecular formula:C7H13N
- Molecular Weight:111.18
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Yield: 94%
Reaction Conditions:
with potassium carbonate in toluene at 20; for 15 h;
Steps:
16.1 Step 1:
Step 1:
Synthesis of N,N-diethylprop-2-yn-1-amine
To a solution of diethylamine (0.46 ml, 1 eq) in toluene (10 ml) was added with K2CO3(1.23 g, 2 eq) and 3-bromoprop-1-yne (0.56 ml, 1.5 eq).
The mixture was stirred for 15 hr at room temperature and filtered off, and the filtrate was concentrated in vacuo.
The resulting residue was purified with column chromatography to prepare the title compound (0.46 g, 94%).
MS (ESI, m/z): 112.1 [M+H]+.
References:
Dong-A St Co., Ltd.;Choi, Sun-Ho;Im, Weon-Bin;Choi, Sung-Hak;Cho, Chong-Hwan;Moon, Ho-Sang;Park, Jung-Sang;Lee, Min-Jung;Sung, Hyun-Jung;Moon, Jun-Hwan;Song, Seung-Hyun;Lee, Hyung-Keun;Choi, Ji-Hoon;Park, Cheon-Hyoung;Kim, Yoon-Jung;Kim, Jin-Hyuk US2018/86709, 2018, A1 Location in patent:Paragraph 0205-0207
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