ChemicalBook CAS DataBase List 1-Hydroxy-1-cyclopropanecarboxylic acid

1-Hydroxy-1-cyclopropanecarboxylic acid synthesis

6synthesis methods

Product Name:1-Hydroxy-1-cyclopropanecarboxylic acid
CAS Number:17994-25-1
Molecular formula:C4H6O3
Molecular Weight:102.09

33689-29-1 Synthesis

METHYL 1-HYDROXY-1-CYCLOPROPANE CARBOXYLATE, 90

33689-29-1
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$16.00/1g

17994-25-1
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$7.00/100mg

Yield:17994-25-1 85.2%

Reaction Conditions:

with lithium hydroxide in tetrahydrofuran;water at 30; for 12 h;

Steps:

1.2; 2.2 (2) Synthesis of compound 3
Compound 2 (900.0g, 7.76mol, 1.0eq) was dissolved in 9L of tetrahydrofuran and water(5: 2) into the mixed solution, then add lithium hydroxide in batches(1862.4g, 77.6mol, 10eq). The reaction solution was heated to 30 ° C in an oil bath and reacted for 12 hours.After the reaction is complete, cool to room temperature and adjust the pH of the reaction to 5-6 with aqueous hydrochloric acid (2N).Extract three times with ethyl acetate (3 * 5L), combine the organic phases, dry over anhydrous magnesium sulfate, filter,The organic phase was concentrated to obtain the target compound 3 (673.2g, 6.6mol),White solid, yield 85.2%.

References:

Shanghai Tianze Bio-pharmaceutical Co., Ltd.;Li Jinfei CN110862311, 2020, A Location in patent:Paragraph 0034; 0040-0042; 0043; 0046-0047

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