10-METHYLPHENOTHIAZINE synthesis
- Product Name:10-METHYLPHENOTHIAZINE
- CAS Number:1207-72-3
- Molecular formula:C13H11NS
- Molecular Weight:213.3
Yield:1207-72-3 97%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide;mineral oil at 20; for 2 h;Cooling with ice;
Steps:
1
Weighing NaH (60% purity, 1.0g, 25 . 1mmol) is slowly added in the ice water bath in DMF (10 ml) of 50 ml round bottom bottle in, subsequently adding methyl iodide (1.3g, 11 . 04mmol) and compound phenothiazine (2g, 10.0mmol), transfer to room temperature stirring 2h, TLC monitoring after the reaction, water, for extracting DCM (50 ml x 3), magnesium sulfate drying and then concentrated dry, separate the product by silica gel column 1a (2.1g), white solid, melting point: 96 °C, yield 97%.
References:
Guangdong University of Technology;Chen, Huixiong;Pascal, Dao;Guo, Qihui;Ye, Feifei CN106045986, 2016, A Location in patent:Paragraph 0039; 0040; 0041
2234-09-5
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1207-72-3
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