ChemicalBook CAS DataBase List 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole synthesis

6synthesis methods

Product Name:2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
CAS Number:103577-40-8
Molecular formula:C16H14F3N3OS
Molecular Weight:353.36

2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE

128430-66-0
97 suppliers
$113.00/250 mg

134469-07-1
19 suppliers
inquiry

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

103577-40-8
377 suppliers
$7.00/250mg

Yield:103577-40-8 96%

Reaction Conditions:

with benzyl tri-n-butylammonium bromide;sodium hydroxide in methanol at 20; for 3 h;Reagent/catalyst;

Steps:

1.2 (2) Preparation of 2 - [[2- (3-methyl-4- (2,2,2-trifluoroethoxy) pyridyl) methyl] -thio] -1H-benzimidazole
2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine (91 g, 0.38 mol)2-mercaptobenzimidazole (57 g, 0.38 mol),Suspended in methanol (1 L)Benzyltributylammonium bromide (2.15 g, 0.006 mol)A 30% NaOH solution (65 mL) was added dropwise over 1 hour,Room temperature reaction 2h.To the mixture was added 300 mL of water,Stir for 30 minutes.10 ° C with 35% HCl adjusted to pH 9,Precipitation precipitation.filter,Followed by washing with 50% methanol and water.Dried at 50 ° C under vacuum,To give 2 - [[2- (3-methyl-4- (2,2,2-trifluoroethoxy) pyridin-yl) methyl] - thio] -1H- benzimidazole-129g,Yield 96%.

References:

Shijiazhuang Du Zhi Pharmaceutical Technology Co., Ltd.;Fang Yu;Du Yumin CN106543146, 2017, A Location in patent:Paragraph 0025; 0031; 0032; 0041; 0045; 0049; 0053-0069

FullText