5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID METHYL ESTER
- CAS Number:139183-98-5
- Molecular formula:C9H12N2O2
- Molecular Weight:180.2
136117-69-6
114 suppliers
$32.00/500mg
139183-98-5
42 suppliers
$153.00/250mg
Yield:-
Reaction Conditions:
with 5%-palladium/activated carbon;acetic acid at 50; under 1551.49 Torr; for 16 h;
Steps:
342.A methyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6-carboxylate
(1069) To a 50 ml pressure bottle were placed methyl imidazo[1,2-a]pyridine-6-carboxylate (0.26 g), acetic acid (10 ml), and wet 5% palladium on carbon (0.052 g). The reaction mixture was stirred for 16 hours at 30 psi and 50° C. The solid was filtered off, and the filtrate was concentrated. The residue was taken up in ethyl acetate. It was then washed with saturated sodium bicarbonate, brine, dried over MgSO4, filtered, and concentrated. The residue was purified by flash column chromatography on silica gel using 10-100% ethyl acetate in hexanes to provide the title compound.
References:
US10213433,2019,B2 Location in patent:Page/Page column 258-259