ChemicalBook CAS DataBase List 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
CAS Number:139756-00-6
Molecular formula:C8H11N3O4
Molecular Weight:213.19

1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID

139755-99-0
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1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

139756-00-6
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Yield:139756-00-6 92.4%

Reaction Conditions:

with sulfuric acid;nitric acid at 50 - 70;

Steps:

3 Example 3
40.00 g of 1-methyl-3-propylpyrazole-5-carboxylic acid was dissolved in 227.21 g of concentrated sulfuric acid at 50 ° C, 64.08 g of mixed acid was slowly added dropwise and reacted at 65-70 ° C for 4.5- Dropping to room temperature, adding 855.34g of ice water, stirring, immediately precipitation of solid 50.21g, water 6.65%, yield 92.40%.From the above examples, the synthesis process of the invention has the advantages of simple operation, high product yield, and concentrated sulfuric acid can be recycled, greatly reducing the industrial cost.

References:

Jilin Medical College;Liang, Chengwu;Chang, Sheng;Zhang, Xiurong;Ling, Zhiyi;Feng, Bo;Jin, Ying;Li, Xiaoguang CN105622512, 2016, A Location in patent:Paragraph 0022

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133261-07-1 Synthesis