2,6-Piperidinedione, 3-(1,3-dihydro-7-hydroxy-1-oxo-2H-isoindol-2-yl)- synthesis
- Product Name:2,6-Piperidinedione, 3-(1,3-dihydro-7-hydroxy-1-oxo-2H-isoindol-2-yl)-
- CAS Number:1416990-10-7
- Molecular formula:C13H12N2O4
- Molecular Weight:260.25
1416990-15-2
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1416990-10-7
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Yield:1416990-10-7 26%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 0.5 h;
Steps:
3.D Step D:
[0448] To a solution of compound 5 (0.5 mmol) in dichloromethane (2.0 ml) was added TFA (2 mmol). The reaction stirred at room temperature for 0.5h. The reaction was poured into water and extracted (2x) with dichloromethane. The combined organic layers were dried over magnesium sulfate, filtered and concentrated. The crude residue was purified by HPLC. Yield: 26%.
References:
WO2021/126973,2021,A1 Location in patent:Paragraph 0444; 0448
6555-40-4
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$30.00/1g
1416990-10-7
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24666-56-6
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$8.00/5g
1021440-25-4
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1416990-10-7
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