ChemicalBook CAS DataBase List 2-(2-Pyridyl)benzoxazole

2-(2-Pyridyl)benzoxazole synthesis

13synthesis methods

Product Name:2-(2-Pyridyl)benzoxazole
CAS Number:32959-62-9
Molecular formula:C12H8N2O
Molecular Weight:196.2

2-Pyridinecarboxamide, N-(2-iodophenyl)-

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Yield: 75%

Reaction Conditions:

with 1-(N-ferrocenylmethyl)benzimidazole grafted onto Merrifield resin in dimethyl sulfoxide at 140; for 17 h;

Steps:

4.4. General procedure for the synthesis of 2-substituted benzoxazoles
General procedure: A mixture of N-(2-iodoaryl)benzamides/acetamide/propanamide (1 mmol) and [FemMerBenz]OH (100 mg, 0.12 mmol) in dry DMSO (5 mL) was stirred for 15-24 h at 140 C. The reaction mixture was filtered and quenched withwater (10 mL). The resultant solutionwas extracted with ethyl acetate (3*10 mL). The combined organic layers were dried over Na2SO4. The solventwas evaporated in vacuo to give the crude product, which was purified by column chromatography over silica gel using hexane/EtOAc as the eluent.

References:

Jadhav, Jagannath;Gaikwad, Vipul;Kurane, Rajanikant;Salunkhe, Rajashri;Rashinkar, Gajanan [Tetrahedron,2013,vol. 69,# 14,p. 2920 - 2926]

98-98-6 Synthesis