ChemicalBook CAS DataBase List 2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE

2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE synthesis

10synthesis methods

Product Name:2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE
CAS Number:651-80-9
Molecular formula:C7HF7
Molecular Weight:218.07

4-TRIFLUOROMETHYL-2,3,5,6-TETRAFLUOROTHIOPHENOL

651-84-3
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$45.00/1 g

651-80-9
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$20.00/1g

Yield: 66 %Chromat.

Reaction Conditions:

with chloroform;sodium hydroxide in 1,4-dioxane;water at 88; for 9 h;Inert atmosphere;Reagent/catalyst;

Steps:

Reaction of thiol (1d) with CHCl3.
A mixture of 1.50 g (6.00 mmol) of thiol 1d, 2.47 g (20.69 mmol) of CHCl3, and 2.83 g (70.75 mmol) of NaOH in 10 mL of 1,4-dioxane and 8 mL of water after heating (9 h, 88°C) was subjected to steam distillation to obtain 1.17 g of amixture containing (GLC) 15% of initial thiol 1d and 65% of arene 5d. Yield of arene 5d in the mixture 58%, 66% calculated on reacted thiol 1d.

References:

Bredikhin;Maksimov;Gatilov, Yu. V.;Kireenkov;Platonov [Russian Journal of Organic Chemistry,2015,vol. 51,# 11,p. 1551 - 1559][Zh. Org. Khim.,2015,vol. 51,# 11,p. 1582 - 1590,9]

617-86-7 Synthesis