2,3-DIMETHYLQUINOXALINE synthesis
- Product Name:2,3-DIMETHYLQUINOXALINE
- CAS Number:2379-55-7
- Molecular formula:C10H10N2
- Molecular Weight:158.2
16214-27-0
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2379-55-7
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Yield: 92%
Reaction Conditions:
with saccharin in methanol at 20; for 0.166667 h;
Steps:
General Procedure for the Quinoxalines and Pyrido[2,3-b]pyrazines Syntheses
General procedure: Saccharin (92 mg, 0.5 mmol) and the required 1,2-arylenediamine 1 (10 mmol) were successively added to the required 1,2-dicarbonyl compound 2 (10 mmol) in methanol (10 mL). The mixture was stirred for the appropriate time at room temperature (reaction monitored by thin-layer chromatography), and poured intowater (10 mL). The solid was collected by filtration and dried to afford the product 3. The isomers 3j and 3j' were separated by chromatography over silica gel (CH2Cl2-AcOEt 8:2). All products were characterized by 1H NMR and 13C NMR and were identified by comparison of the spectral data and melting points with those reported in literature (supporting information).
References:
Lassagne, Frederic;Chevallier, Floris;Mongin, Florence [Synthetic Communications,2014,vol. 44,# 1,p. 141 - 149] Location in patent:supporting information
