2,4,6-TRIMETHOXYPYRIMIDINE synthesis
- Product Name:2,4,6-TRIMETHOXYPYRIMIDINE
- CAS Number:13106-85-9
- Molecular formula:C7H10N2O3
- Molecular Weight:170.17
3764-01-0
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13106-85-9
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$31.00/250mg
Yield:-
Reaction Conditions:
with sodium methylate;magnesium sulfate in methanol
Steps:
19 Preparation of 2,4,6-trimethoxypyrimidine
EXAMPLE 19 Preparation of 2,4,6-trimethoxypyrimidine 13.5 ml of 2,4,6-trichloropyrimidine in 80 ml of methanol are added dropwise, with cooling and under an argon protective gas to 106 ml of a 5.4M solution of sodium methoxide in methanol (0.576 mol). After the mixture has been refluxed for 90 minutes, the solvent is removed and the residue is poured into water. The mixture is extracted twice with toluene, the organic phases are dried using MgSO4 and filtered, and the solvent is removed. The target product is obtained in quantitative yield. NMR data: signals at 3.95 ppm (singlet for 9H) and 5.7 ppm (singlet for 1H). The bromination step is carried out as described under Example 12.2. NMR data: signals at 4 ppm (singlet for 9H).
References:
Ciba-Geigy Corporation US5340701, 1994, A
3764-01-0
400 suppliers
$6.00/5g
124-41-4
683 suppliers
$12.00/25g
13106-85-9
95 suppliers
$31.00/250mg