ChemicalBook CAS DataBase List 2,7-Dibromo-9H-fluoren-9-one

2,7-Dibromo-9H-fluoren-9-one synthesis

11synthesis methods

Product Name:2,7-Dibromo-9H-fluoren-9-one
CAS Number:14348-75-5
Molecular formula:C13H6Br2O
Molecular Weight:337.99

16433-88-8 Synthesis

16433-88-8
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$6.00/5g

14348-75-5
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$14.00/1g

Yield:14348-75-5 98%

Reaction Conditions:

with chromium(VI) oxide;acetic acid at 20; for 12 h;

Steps:

1

Synthesis of 2,7-dibromofluorenone (scheme 1)This compound was prepared following the procedure reported in the literature {Tetrahedron 2006, 62, 3355- 3361)."A mixture of 2,7-dibromofluorene (10.0 g, 30.9 mmol) and CrO₃ (12 g, 0.12 mol) suspended in 250 mL acetic acid, and stirred at room temperature for 12 h. The resulting yellow precipitate was collected by suction filtration, washed with water thoroughly, and dried under vacuum to provide the product as yellow solid (10.1 g, 98% yield). ¹H NMR (400 MHz, CDC1₃)7.77 (s, 2H), 7.63 (d, 2H, J = 8.0 Hz), 7.39 (d, 2H, J = 8.0 Hz) .

References:

WO2010/96019,2010,A1 Location in patent:Page/Page column 24-25