ChemicalBook CAS DataBase List 2-Amino-5-nitrothiazole

2-Amino-5-nitrothiazole synthesis

6synthesis methods

Product Name:2-Amino-5-nitrothiazole
CAS Number:121-66-4
Molecular formula:C3H3N3O2S
Molecular Weight:145.14

The synthesis of 2-amino-5-nitrothiazole:first the synthesis of 2-aminothiazole. The 2-aminothiazole then is treated with a mixture of nitric and sulfuric acids to give 2-nitramino-thiazole which, upon heating, rearranges to 2-amino-5-nitrothiazole.

96-50-4 Synthesis

96-50-4
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121-66-4
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Yield:121-66-4 59%

Reaction Conditions:

with sulfuric acid;nitric acid at 15;Cooling with ice;

Steps:

1.1 1. Synthesis of compound 2:

Add 20g (0.2mol) of compound 1:2-aminothiazole in a 250mL flask,Add 30mL concentrated sulfuric acid and 10mL nitric acid (40%) dropwise under ice bath,Stir at 15°C overnight.Use 1M NaOH to adjust the pH to 8, filter the precipitate, and rinse with plenty of water.Using petroleum ether: ethyl acetate 5:1 as the mobile phase, it was passed through a silica gel column to obtain 17.1 g of compound 2 (yield 59%).

References:

CN113694060,2021,A Location in patent:Paragraph 0013; 0041-0044

Ethenamine, N,N-dimethyl-2-nitro-, (1E)-

73430-27-0
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17356-08-0
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121-66-4
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References

59024-01-0
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121-66-4
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140-40-9
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121-66-4
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2719-23-5
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121-66-4
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References

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